MDM2 (violet, foreground) binds to p53 (blue). Thus, the tumor suppressor p53 cannot bind to DNA and trigger the self-destruction of the cell. In the cytoplasm, a domain of MDM2 and MDMX (red) add ubiquitin to p53 targeting it for destruction by proteasomes.MDM2 may be a target for cancer chemotherapy.

MDM2 (violet, foreground) binds to p53 (blue). Thus, the tumor suppressor p53 cannot bind to DNA and trigger the self-destruction of the cell. In the cytoplasm, a domain of MDM2 and MDMX (red) add ubiquitin to p53 targeting it for destruction by proteasomes.MDM2 may be a target for cancer chemotherapy. - 132279915

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